Curriculum Vitae

                                   HongJie Zhang      

Department of Gastroenterology, the First Affiliated Hospital of Nanjing

Medical University, Nanjing 210029, P.R. China  

Mailing Add: 300# Guangzhou Road, Nanjing, 210029

E-mail:  hjzhang06@163.com

Current Appointments: The Deputy director of Dept of Gastroenterology,

the First Affiliated Hospital of Nanjing Medical University. 

Education

09/2005~06/2010                  Ph. D (Biology)

The School of Life Sciences, Nanjing University, Nanjing, P. R. China  

09/1994~07/1997                   Master degree (Gastroenterology)

                                               Nanjing Medical University, Nanjing, P. R. China  

09/1984~07/1989                   MD (Clinical medicine)

Xuzhou Medical College, Xuzhou, P.R. China

Professional Experience

03/2008~06/2009                 Research scholar, Medical center,

 The University of Chicago

07/2012- present                  Professor, Dept of Gastroenterology,

                                             The First Affiliated Hospital of Nanjing

                                             Medical University, China

06/2002~07/2012                Associate Professor, Dept of Gastroenterology, 

                                            The First Affiliated Hospital of Nanjing

                                            Medical University, China

09/1997~05/2002                Lecturer, Dept of Gastroenterology,

                                            The First Affiliated Hospital of Nanjing

                                            Medical University, China

07/1996~07/1997                Assistant, Chief Resident, Dept of Gastroenterology, 

                                            The First Affiliated Hospital of Nanjing

                                            Medical University, China

08/1989~08/1994                Resident, Dept of Internal Medicine,

                                            The General Hospital of Xuzhou Mineral Bureau,

                                             P.R. China 

ORGANIZATIONAL ACTIVIITES

1. Member, the IBD Group of Digestive Disease Branch, Chinese Medical Association.

2. Executive Committee Member, the Digestive Disease Branch of Jiangsu Medical Association

3. The leader of IBD group, Jiangsu Provincial Medical Association

4. Member, Chinese women Medical Association

5. Chairman of Digestive Rehabilitation Committee of Jiangsu Rehabilitation Medical Association

6. Member, the Transfer Group of Digestive Biology Sample Bank of Chinese Medical Association

7. Vice Chairman, the Inflammatory Bowel Disease Professional Committee of Jiangsu Society of Traditional Chinese Medicine

8. Member, Capsule Endoscopy Cooperation Group, Digestive Endoscopy Branch, Chinese Medical Association

RESEARCH ACTIVITIES

Grants 

1.“Fusobacterium nucleatum promotes intestinal immunogenic DC/Th17 differentiation in Crohn's disease by inhibiting Synbindin”was supported by The National Natural Science Foundation of China. (2024-2027). I am in charge of the project.

2.“The formation mechanism: aryl hydrocarbon receptor mediated the abnormal differentiation of Treg cells by regulating immunotolerant dendritic cells formation in Crohn's disease” was supported by The National Natural Science Foundation of China. (2021-2024). I am in charge of the project.

3.“The pathogenic mechanism of aryl hydrocarbon receptor mediated abnormal differentiation of intestinal ILC3/ILC1 in Crohn's disease” was supported by The National Natural Science Foundation of China. (2018-2021). I am in charge of the project.

4.“the pathogenesis mechanism of miR-124 mediated Th17/Treg cell differentiation imbalance in Crohn's disease” was supported by The National Natural Science Foundation of China. (2015-2018). I am in charge of the project.

5.“The molecular mechanism of miRNA-19b in the regulation of Th17 cell differentiation in the formation of Crohn's disease” was supported by The National Natural Science Foundation of China. (2013-2016). I am in charge of the project.

6. “The role of miRNAs in the prediction of disease activity and recurrence of IBD” –“135 project” organized and implemented by Jiangsu Province government(2011-2016). I am in charge of this project.

7.“The Effect of UCP2 on the Secretion of GLP-1 from Gastrointestinal Endocrine L-cells” was funded by The National Natural Science Foundation of China. (2007-2010). I am in charge of the project.

8. “Study on the role of UCP2 in pathogenesis in colon cancer” was funded by The Science and Technology Committee of Jiangsu Province. (2006-2009). I am in charge of the project.

 9. “Study on the pathogenesis of 2 diabetes mellitus” organized and implemented by the Ministry of Science and Technology (973 Program). I am one of the principal investigators. (2006-2009)

10. “Study on the mechanism of the effect of CO on ICC in slow-transmission model” was funded by The Science and Technology Committee of Jiangsu Province. (2004-2007). I was one of the principal investigators

11. “Study on the relationship between the ICC and slow-transmission constipation” –“135 project” organized and implemented by Jiangsu Province government. I am one of the principal investigators

12. “Expression and mutual relationship of tumor suppression gene and apoptosis regulating gene in gastric carcinoma” was funded by The Natural Scientific Foundation of Jiangsu Province (1997-2000). I was one of the investigators.

  Main Publications:

1. Xiaojing Zhao1, Wenjing Yang2, Tianming Yu2, Yu Yu3, Xiufang Cui 4, Zheng Zhou3, Hui Yang3, Yanbo Yu3, Anthony J Bilotta3, Suxia Yao3, Jimin Xu5, Jia Zhou5, Gregory S Yochum6, Walter A Koltun7, Austin Portolese7, Defu Zeng8, Jingwu Xie9, Iryna V Pinchuk10, Hongjie Zhang4, Yingzi Cong. Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts.Gastroenterology 2023 Jan;164(1):89-102

2. Chenjing Xu # 1, Ziping Ye # 1, Wenyu Jiang # 1, Shu Wang 1, Hongjie Zhang 2.Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway. Mol Med 2023 Dec 13;29(1):169

3. Mao X, Ma J, Jiao C, Tang N, Zhao X, Wang D, Zhang Y, Ye Z, Xu C, Jiang J, Wu S, Cui X, Zhang H, Qiu X.Faecalibacterium prausnitzii Attenuates DSS-Induced Colitis by Inhibiting the Colonization and Pathogenicity of Candida albicans. Mol Nutr Food Res 2021 Nov;65(21):e2100433

4. Chenjing Xu1, Wenyu Jiang1, Lu Wang1, Xiaqiong Mao1, Ziping Ye1, Hongjie Zhang.Intestinal Ultrasound for Differentiating Fibrotic or Inflammatory Stenosis in Crohn's Disease: A Systematic Review and Meta-analysis.J Crohns Colitis 2022 Sep 8;16(9):1493-1504

5. Shu Wang1, Ying Xu1, Lu Wang1, Junjie Lin1, Chenjing Xu1, Xiaojing Zhao1, Hongjie Zhang1.TolDC Restores the Balance of Th17/Treg via Aryl Hydrocarbon Receptor to Attenuate Colitis.Inflamm Bowel Dis 2024 Mar 2:izae022

6. Ma J, Zhou X, Zhang H*. An Unusual Cause of Chronic Diarrhea. Clin Gastroenterol Hepatol 2020.

7. Zhao X, Li J, Ma J, Jiao C, Qiu X, Cui X, Wang D, Zhang H*. MiR-124a Mediates the Impairment of Intestinal Epithelial Integrity by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease. INFLAMMATION 2020.

8. Yang Y, Cui X, Li J, Wang H, Li Y, Chen Y, Zhang H*. Clinical evaluation of vitamin D status and its relationship with disease activity and changes of intestinal immune function in patients with Crohn's disease in the Chinese population. Scand J Gastroenterol 2020: 1-10.

9. Qiu X, Zhao X, Cui X, Mao X, Tang N, Jiao C, Wang D, Zhang Y, Ye Z, Zhang H*. Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn's disease. Therap Adv Gastroenterol 2020, 13: 320807230.

10. Cui X, Zhao X, Wang Y, Yang Y, Zhang H*. Glucagonlike peptide1 analogue exendin4 modulates serotonin transporter expression in intestinal epithelial cells. Mol Med Rep 2020;21:1934-1940.

11. Mao X#, Qiu X#, Jiao C#,  Lu M,  Zhao X,  Li X,  Li J,  Ma J,  Zhang H*. Candida albicans SC5314 inhibits NLRP3/NLRP6 inflammasome expression and dampens  human intestinal barrier activity in Caco-2 cell monolayer model. CYTOKINE 2019; 126: 154882.

12. Hai-Yang Wang, Yi Li, Jia-Jia Li, Chun-Hua Jiao, Xiao-Jing Zhao, Xue-Ting Li, Mei-Jiao Lu, Xia-Qiong Mao, Hong-Jie Zhang*. Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease. World J Clin Cases 2019 August 26; 7(16): 2189-2203.

13. Li J, Zhao X, Li X, Lu M, Zhang H*. Systematic Review with Meta-Analysis: Fecal Calprotectin as a Surrogate Marker for Predicting Relapse in Adults with Ulcerative Colitis. Mediators Inflamm. 2019; 2019: 2136501.

14. Zhao X, Li L, Li X, Li J, Wang D, Zhang H*. The Relationship between Serum Bilirubin and Inflammatory Bowel Disease. Mediators Inflamm. 2019; 2019: 5256460.

15.  Yingdi Zhang, Xiaojing Zhao, Yunjuan Zhu, Jingjing Ma, Haiqin Ma , Hongjie Zhang*. Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs.  Mediators of Inflammation Volume 2018, Article ID 9416391, 11 pages.

16. Hai-Qin Ma, Ting-Ting Yu, Xiao-Jing Zhao, Yi Zhang, Hong-Jie Zhang*.  Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease World J Gastroenterol 2018 April 7; 24(13): 1464-1477.

17. M. J. Lu, X. Y. Qiu, X. Q. Mao, X. T. Li, H. J. Zhang*. Systematic review with meta-analysis: thiopurines decrease the risk of colorectal neoplasia in patients with inflammatory bowel disease.  Aliment Pharmacol Ther. 2018;47:318–331.

18. Xinyun Qiu, Jingjing Ma, Chunhua Jiao, Xiaqiong Mao, Xiaojing Zhao, Meijiao Lu, Kai Wang and Hongjie Zhang*. Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis Oncotarget, 2017, Vol. 8, (No. 64).

19.  XiaojingZhao, ChangchengZhou, Jingjing Ma1, YunjuanZhu, Min Sun, PeixueWang, Yi Zhang, Haiqin Ma, Hongjie Zhang*.  Efficacy and safety of rectal 5-aminosalicylic acid versus corticosteroids in active distal ulcerative colitis: a systematic review and network meta-analysis. Scientific Reports | 7:46693 | DOI: 10.1038/srep46693.

20.  Xiaojing Zhao; Changcheng Zhou; Han Chen; Jingjing Ma; Yunjuan Zhu; Peixue Wang; Yi Zhang; Haiqin Ma; Hongjie Zhang*. Efficacy and safety of medical therapy for low bone mineral density in patients with Crohn disease: A systematic review with network meta-analysis.  Medicine. 96(11):e6378, MAR 2017.

21. Jing-Jing Ma, Ying Wang, Xiao-Min Xu, Jie-Wen Su, Wen-Yu Jiang, Jian-Xia Jiang, Lin Lin, Dao-Quan Zhang, Jing Ding, Li Chen, Ting Jiang, Ying-Hong Xu, Gui Tao, Hong-Jie Zhang*. Capsule endoscopy and single-balloon enteroscopy in small bowel diseases: Competing or complementary? World J Gastroenterol. Dec 28, 2016; 22(48): 10625-10630.

22. Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang*. Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis. Oncotarget, 2017, Vol. 8, (No. 1), pp: 1031-1045.

23. Weimei Zhou, Jiewen Su, and Hongjie Zhang*. Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis The Journal Of Alternative And Complementary Medicine Volume 00, Number 0, 2016, pp. 1–10.

24. Xu, Xiao-Min; Zhang, Hong-Jie*. 2016 Inflammatory Bowel Disease: Global view miRNAs as new molecular insights into inflammatory bowel disease: crucial regulators in autoimmunity and inflammation. World J Gastroenterol 2016 February 21; 22(7): 2206-2218.

25. Xiuqin Cheng,1,# Xiaofei Zhang,1,3,# Jiewen Su,1,# Yingdi Zhang,1 Weimei Zhou,1 Jun Zhou,1 Cheng Wang,2 Hongwei Liang,2 Xi Chen,2 Ruihua Shi,1 Ke Zen,2 Chen-Yu Zhang,2 and Hongjie Zhang*1. miR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn’s disease.Sci Rep. 2015; 5: 10397.Published online 2015 May 22. doi:  10.1038/srep10397.

26. Jie Wen SU, Jing Jing MA，Zhang HJ*.Use of antibiotics in patients with Crohn’s disease:A systematic review and meta-analysis. Journal of Digestive Diseases 2015; 16;58–66.

27. Cui XF, Zhou WM, Yang Y, Zhou J, Li XL, Lin L, Zhang HJ*. Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World J Gastroenterol 2014 October 7; 20(37): 13521-13529.

28. Yang Y, Cui X, Chen Y, Wang Y, Li X, Lin L, Zhang H*. Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity. J Physiol Pharmacol. 2014 Jun;65(3):349-57.

29. Jiang W1, Su J, Zhang X, Cheng X, Zhou J, Shi R, Zhang H. Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease. Inflamm Res. 2014 Nov;63(11):943-50.

30. Zhang H, Kuai X, Ji Z, Li Z, Shi R. Over-Expression of Small Ubiquitin-Related Modifier-1 and Sumoylated p53 in Colon Cancer. Cell Biochem Biophys. 2013 May 3.

31. Zhang X, Yu P, Wang Y, Jiang W, Shen F, Wang Y, Tu H, Yang X, Shi R, Zhang H. Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population. Inflamm Res. 2013 Aug;62(8):743-50.

32. Chen Y, Li Z, Yang Y, Lin L, Zhang H. Role of glucagon-like peptide-1 in the pathogenesis of experimental irritable bowel syndrome rat models. Int J Mol Med. 2013 Mar;31(3):607-13.

33. Pengli Yu, #, Fangcheng Shen, #, Xiaofei Zhang, Risheng Cao, Xiaodan Zhao, Pengfei Liu, Huiming Tu, Xiaozhong Yang, Ruihua Shi*, Hongjie Zhang*. Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population. PLoS ONE 2012;7(9):e44380.

34. Zhang H, Kuai XY, Yu P, Lin L, Shi R. Protective Role for Uncoupling Protein-2 against DSS-induced Colitis.  J Gastroenterol Hepatol. 2012 Mar;27(3):603-8.

35. Kuai XY, Ji ZY, Zhang HJ. Mitochondrial uncoupling protein 2 expression in colon cancer and its clinical significance. World J Gastroenterol. 2010 December 7; 16(45): 5773–5778.

36. X Chen#, X Guo#, H Zhang#, Y Xiang, J Chen, Y Yin, X Cai, K Wang, G Wang, Y Ba, L Zhu, J Wang, R Yang, Y Zhang, Z Ren, K Zen, J Zhang and C-Y Zhang. Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene. 2009;28:1385-1392.

37. Zhang H, Yan Y, Shi R, Lin Z, Wang M, Lin L. Correlation of gut hormones with irritable bowel syndrome. Digestion. 2008;78(2-3):72-6.

38. Jiang J, Zhang H, Tang Q, Hao B, Shi R. Expression of HIWI in human hepatocellular carcinoma. Cell Biochem Biophys. 2011 Sep;61(1):53-8.

39. Zhu L, G Sun, Zhang H, Sun G, Zhang Y, Chen X, Jiang X, Jiang X, Krauss S, Xiang Y, Zhang CY. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS ONE. 2009;4 (1):e4182.

40. Li S, Chen X, Zhang H, Liang X, Xiang Y, Zen K, Zhang CY. Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res. 2009 Sep; 50(9):1756-65.

41. Shi R, Xu S, Zhang H, Ding Y, Sun G, Huang X, Chen X, Li X, Yan Z, Zhang G.Prevalence and risk factors for Helicobacter pylori infection in Chinese populations. Helicobacter. 2008 Apr;13(2):157-65.

42. Bian Z, Li L, Cui J, Zhang H, Liu Y, Zhang CY, Zen K. Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. J Pathol. 2011 Dec;225(4):544-53.

43. Xiuyun Shen, Ruihua Shi, Hongjie Zhang, Yang Zhao, Ruyang Zhang. The Toll-like receptor 4 (TLR4) D299G and T399I polymorphisms are associated with Crohn’s disease and ulcerative colitis: a meta-analysis. Digestion, 2010;81:69-77.  

主任医师，教授，博士生导师

中华医学会消化病学分会IBD学组委员

中华医学会消化内镜分会胶囊内镜协作组委员

江苏省医学会消化病学分会常委兼IBD学组组长

江苏省康复医学会消化康复专委会主任委员

省中西医结合分会炎症性肠病多学科协作专委会副主委

省中医药学会IBD专委会副主委

江苏省333高层次人才培养—中青年科学技术带头人

江苏省“强卫工程”―医学重点人才