My doctoral training was focused on nonlinear dynamics and fractal physiology. After I obtained my PhD in 2005, I was enrolled into Harvard Medical School for my postdoctoral training. Supported by a number of NIH grants including the KL2 award from the Harvard Clinical and Translational Science Center Harvard Catalyst and the NIH K99/R00 award, I fulfilled a multidisciplinary training in sleep/circadian biology, aging, neurobiology, and system biology. During the past 20 years, I have been applying and developing nonlinear analytical tools to examine neurophysiological functions and their alterations with aging and in diseases. To promote such translational research in Sleep Medicine, I have established the Medical Biodynamics Program within the Division of Sleep and Circadian Disorders at Brigham & Women’s Hospital. The research in our group has been continuously funded by the National Institutes of Health during the last 11 years. We currently have 8 research grants including two NIH R01s and one NIH R03 to investigate sleep/circadian control and the relevance to cognitive and brain function decline in the elderly.